Publications

On-target off-tumor toxicity of claudin18.2-directed CAR-T cells in preclinical models.

Birocchi F, Almazan AJ, Parker A, et al. On-target off-tumor toxicity of claudin18.2-directed CAR-T cells in preclinical models. Nature communications. 2025;16(1):9650. doi:10.1038/s41467-025-61858-zGoogle Scholar PubMed DOI

Modeling and addressing on-target/off-tumor toxicity of claudin 18.2 targeted immunotherapies.

Carstens EJ, Takahashi K, Sakamoto N, et al. Modeling and addressing on-target/off-tumor toxicity of claudin 18.2 targeted immunotherapies. Nature communications. 2025;16(1):9651. doi:10.1038/s41467-025-65148-6Google Scholar PubMed DOI

Myeloid cells mediate interferon-driven resistance to immunotherapy in advanced renal cell carcinoma.

Bi K, Kashima S, Camp SY, et al. Myeloid cells mediate interferon-driven resistance to immunotherapy in advanced renal cell carcinoma. Immunity. 2025. doi:10.1016/j.immuni.2025.10.013Google Scholar PubMed DOI

Microscaled Cell Surface Proteomics for Cryo-preserved Cells and Tissue Samples.

Thorup JR, Johnston SA, Haines M, et al. Microscaled Cell Surface Proteomics for Cryo-preserved Cells and Tissue Samples. Molecular & cellular proteomics : MCP. 2025:101437. doi:10.1016/j.mcpro.2025.101437Google Scholar PubMed DOI

Mendelian Randomization Suggests a Causal Link Between Glycemic Traits and Thoracic Aortic Structures and Diseases.

Daria T, Iyer K, Alkhairo H, et al. Mendelian Randomization Suggests a Causal Link Between Glycemic Traits and Thoracic Aortic Structures and Diseases. JACC. Basic to translational science. 2025:101390. doi:10.1016/j.jacbts.2025.101390Google Scholar PubMed DOI

Incidentally identified aortic dissection in a Great Pyrenees dog.

Melhorn H, Sha M, Kurihara M, Megquier K, Aronson R, Yang V. Incidentally identified aortic dissection in a Great Pyrenees dog. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology. 2025;62:170-175. doi:10.1016/j.jvc.2025.09.007Google Scholar PubMed DOI

Concurrent Chiari malformation type I and hydrocephalus: Integrating mechanistic and pathophysiological insights toward a unified management paradigm.

Davalan W, Mehta NH, Jackson EM, et al. Concurrent Chiari malformation type I and hydrocephalus: Integrating mechanistic and pathophysiological insights toward a unified management paradigm. Experimental neurology. 2025:115535. doi:10.1016/j.expneurol.2025.115535Google Scholar PubMed DOI

Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database.

Gudmundsson S, Singer-Berk M, Stenton SL, et al. Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database. Nature communications. 2025;16(1):9623. doi:10.1038/s41467-025-61698-xGoogle Scholar PubMed DOI

IL-12-releasing nanoparticles for effective immunotherapy of metastatic ovarian cancer.

Pires IS, Covarrubias G, Gomerdinger VF, et al. IL-12-releasing nanoparticles for effective immunotherapy of metastatic ovarian cancer. Nature materials. 2025. doi:10.1038/s41563-025-02390-9Google Scholar PubMed DOI

An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy.

Huffman JE, Gaziano L, Sayed ZRA, et al. An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy. Nature genetics. 2025. doi:10.1038/s41588-025-02372-2Google Scholar PubMed DOI