Obesity

Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance.

Jersin RÅ, Tallapragada DSP, Madsen A, et al. Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance. Diabetes. 2021;70(3):680-695. doi:10.2337/db20-0096Google Scholar PubMed DOI

Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of and .

Sobreira DR, Joslin AC, Zhang Q, et al. Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of and . Science (New York, N.Y.). 2021;372(6546):1085-1091. doi:10.1126/science.abf1008Google Scholar PubMed DOI

IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis.

Yan S, Kumari M, Xiao H, et al. IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis. The Journal of clinical investigation. 2021;131(7). doi:10.1172/JCI144888Google Scholar PubMed DOI

Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells.

Li J, Li E, Czepielewski RS, et al. Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells. Cell metabolism. 2021;33(7):1449-1465.e6. doi:10.1016/j.cmet.2021.04.019Google Scholar PubMed DOI

A distribution-centered approach for analyzing human adipocyte size estimates and their association with obesity-related traits and mitochondrial function.

Honecker J, Weidlich D, Heisz S, et al. A distribution-centered approach for analyzing human adipocyte size estimates and their association with obesity-related traits and mitochondrial function. International journal of obesity (2005). 2021;45(9):2108-2117. doi:10.1038/s41366-021-00883-6Google Scholar PubMed DOI

Comprehensive genomic analysis of dietary habits in UK Biobank identifies hundreds of genetic associations.

Cole JB, Florez JC, Hirschhorn JN. Comprehensive genomic analysis of dietary habits in UK Biobank identifies hundreds of genetic associations. Nat Commun. 2020;11(1):1467. doi:10.1038/s41467-020-15193-0Google Scholar PubMed DOI

Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome.

Hsu YHH, Astley CM, Cole JB, et al. Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome. International journal of obesity (2005). 2020;44(7):1596-1606. doi:10.1038/s41366-020-0603-xGoogle Scholar PubMed DOI

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.

Oguri Y, Shinoda K, Kim H, et al. CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell. 2020;182(3):563-577.e20. doi:10.1016/j.cell.2020.06.021Google Scholar PubMed DOI

Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits.

Glastonbury CA, Pulit SL, Honecker J, et al. Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits. PLoS computational biology. 2020;16(8):e1008044. doi:10.1371/journal.pcbi.1008044Google Scholar PubMed DOI

Adipocytes fail to maintain cellular identity during obesity due to reduced PPARγ activity and elevated TGFβ-SMAD signaling.

Roh HC, Kumari M, Taleb S, et al. Adipocytes fail to maintain cellular identity during obesity due to reduced PPARγ activity and elevated TGFβ-SMAD signaling. Molecular metabolism. 2020;42:101086. doi:10.1016/j.molmet.2020.101086Google Scholar PubMed DOI