Obesity

BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis.

Verkerke ARP, Wang D, Yoshida N, et al. BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis. Cell. 2024;187(10):2359-2374.e18. doi:10.1016/j.cell.2024.03.030Google Scholar PubMed DOI

Light-responsive adipose-hypothalamus axis controls metabolic regulation.

Tsuji T, Tolstikov V, Zhang Y, et al. Light-responsive adipose-hypothalamus axis controls metabolic regulation. Nature communications. 2024;15(1):6768. doi:10.1038/s41467-024-50866-0Google Scholar PubMed DOI

Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue.

Wang CH, Tsuji T, Wu LH, et al. Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue. Nature communications. 2024;15(1):7215. doi:10.1038/s41467-024-51579-0Google Scholar PubMed DOI

Phenotyping children and adolescents with obesity using behavioral, psychological, and familial data.

St Fleur RG, Tanofsky-Kraff M, Yanovski JA, Horton NJ, Hirschhorn JN, Field AE. Phenotyping children and adolescents with obesity using behavioral, psychological, and familial data. Obesity (Silver Spring, Md.). 2023;31(12):3016-3024. doi:10.1002/oby.23893Google Scholar PubMed DOI

Pediatric Features of Genetic Predisposition to Polycystic Ovary Syndrome.

Zhu J, Eliasen AU, Aris IM, et al. Pediatric Features of Genetic Predisposition to Polycystic Ovary Syndrome. The Journal of clinical endocrinology and metabolism. 2023. doi:10.1210/clinem/dgad533Google Scholar PubMed DOI

A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes.

Glunk V, Laber S, Sinnott-Armstrong N, et al. A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes. Nature metabolism. 2023;5(5):861-879. doi:10.1038/s42255-023-00807-wGoogle Scholar PubMed DOI

Identification of a weight loss-associated causal eQTL in and the effects of deficiency on human adipocyte function.

Huang M, Coral D, Ardalani H, et al. Identification of a weight loss-associated causal eQTL in and the effects of deficiency on human adipocyte function. eLife. 2023;12. doi:10.7554/eLife.84168Google Scholar PubMed DOI

Impaired adipocyte SLC7A10 promotes lipid storage in association with insulin resistance and altered BCAA metabolism.

Jersin RÅ, Tallapragada DSP, Skartveit L, et al. Impaired adipocyte SLC7A10 promotes lipid storage in association with insulin resistance and altered BCAA metabolism. The Journal of clinical endocrinology and metabolism. 2023. doi:10.1210/clinem/dgad148Google Scholar PubMed DOI

Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover.

Huang M, Claussnitzer M, Saadat A, Coral DE, Kalamajski S, Franks PW. Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover. Diabetologia. 2023. doi:10.1007/s00125-023-05915-6Google Scholar PubMed DOI

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.

Wieder N, Fried J, Kim C, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Cell metabolism. 2023. doi:10.1016/j.cmet.2023.03.018Google Scholar PubMed DOI