Cancer Program

SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization.

Dai C, Rennhack JP, Arnoff TE, et al. SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization. Cell Rep. 2021;36(4):109443. doi:10.1016/j.celrep.2021.109443Google Scholar PubMed DOI

A phase II study of efficacy, toxicity, and the potential impact of genomic alterations on response to eribulin mesylate in combination with trastuzumab and pertuzumab in women with human epidermal growth factor receptor 2 (HER2)+ metastatic breast cancer

Balch SM, Vaz-Luis I, Li T, et al. A phase II study of efficacy, toxicity, and the potential impact of genomic alterations on response to eribulin mesylate in combination with trastuzumab and pertuzumab in women with human epidermal growth factor receptor 2 (HER2)+ metastatic breast cancer. Breast Cancer Res Treat. 2021. doi:10.1007/s10549-021-06329-xGoogle Scholar PubMed DOI

TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma.

Seong BKA, Dharia NV, Lin S, et al. TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma. Cancer Cell. 2021. doi:10.1016/j.ccell.2021.07.003Google Scholar PubMed DOI

Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.

Garvie CW, Wu X, Papanastasiou M, et al. Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase. Nat Commun. 2021;12(1):4375. doi:10.1038/s41467-021-24495-wGoogle Scholar PubMed DOI

Multi-Center Immune Profiling Mass Cytometry Assay Harmonization.

Sahaf B, Pichavant M, Lee BH, et al. Multi-Center Immune Profiling Mass Cytometry Assay Harmonization. Clin Cancer Res. 2021. doi:10.1158/1078-0432.CCR-21-2052Google Scholar PubMed DOI

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.

Neggers JE, Paolella BR, Asfaw A, et al. Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Rep. 2021;36(2):109367. doi:10.1016/j.celrep.2021.109367Google Scholar PubMed DOI

Cell line-specific network models of ER+ breast cancer identify potential PI3Kα inhibitor resistance mechanisms and drug combinations.

Zañudo JGT, Mao P, Alcon C, et al. Cell line-specific network models of ER+ breast cancer identify potential PI3Kα inhibitor resistance mechanisms and drug combinations. Cancer Res. 2021. doi:10.1158/0008-5472.CAN-21-1208Google Scholar PubMed DOI

Acquired Resistance to KRAS Inhibition in Cancer.

Awad MM, Liu S, Rybkin II, et al. Acquired Resistance to KRAS Inhibition in Cancer. N Engl J Med. 2021;384(25):2382-2393. doi:10.1056/NEJMoa2105281Google Scholar PubMed DOI

Gene fusions create partner and collateral dependencies essential to cancer cell survival.

Gillani R, Seong BKA, Crowdis J, et al. Gene fusions create partner and collateral dependencies essential to cancer cell survival. Cancer Res. 2021. doi:10.1158/0008-5472.CAN-21-0791Google Scholar PubMed DOI

Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence.

Wu Z, Zhou J, Zhang X, et al. Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence. Nat Genet. 2021;53(6):881-894. doi:10.1038/s41588-021-00859-2Google Scholar PubMed DOI