Imaging Platform

High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly.

Berryer MH, Rizki G, Nathanson A, et al. High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly. eLife. 2023;12. doi:10.7554/eLife.80168Google Scholar PubMed DOI

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.

Wieder N, Fried J, Kim C, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Cell metabolism. 2023. doi:10.1016/j.cmet.2023.03.018Google Scholar PubMed DOI

High-dimensional gene expression and morphology profiles of cells across 28,000 genetic and chemical perturbations.

Haghighi M, Caicedo JC, Cimini BA, Carpenter AE, Singh S. High-dimensional gene expression and morphology profiles of cells across 28,000 genetic and chemical perturbations. Nat Methods. 2022. doi:10.1038/s41592-022-01667-0Google Scholar PubMed DOI

Virtual screening for small-molecule pathway regulators by image-profile matching.

Rohban MH, Fuller AM, Tan C, et al. Virtual screening for small-molecule pathway regulators by image-profile matching. Cell Syst. 2022. doi:10.1016/j.cels.2022.08.003Google Scholar PubMed DOI

A New Image for Cell Sorting.

Filby A, Carpenter AE. A New Image for Cell Sorting. N Engl J Med. 2022;386(18):1755-1758. doi:10.1056/NEJMcibr2200971Google Scholar PubMed DOI

Predicting drug polypharmacology from cell morphology readouts using variational autoencoder latent space arithmetic.

Chow YL, Singh S, Carpenter AE, Way GP. Predicting drug polypharmacology from cell morphology readouts using variational autoencoder latent space arithmetic. PLoS Comput Biol. 2022;18(2):e1009888. doi:10.1371/journal.pcbi.1009888Google Scholar PubMed DOI

The new era of quantitative cell imaging-challenges and opportunities.

Bagheri N, Carpenter AE, Lundberg E, Plant AL, Horwitz R. The new era of quantitative cell imaging-challenges and opportunities. Mol Cell. 2022;82(2):241-247. doi:10.1016/j.molcel.2021.12.024Google Scholar PubMed DOI

Imaging flow cytometry

Rees P, Summers HD, Filby A, Carpenter AE, Doan M. Imaging flow cytometry. Nature Reviews Methods Primers. 2022.Google Scholar

2020 BioImage Analysis Survey: Community experiences and needs for the future.

Jamali N, Dobson ET, Eliceiri KW, Carpenter AE, Cimini BA. 2020 BioImage Analysis Survey: Community experiences and needs for the future. Biol Imaging. 2022;1. doi:10.1017/S2633903X21000039Google Scholar PubMed DOI

Morphology and gene expression profiling provide complementary information for mapping cell state.

Way G, Natoli T, Adeboye A, et al. Morphology and gene expression profiling provide complementary information for mapping cell state. Cell systems. 2022;13(11):911-923.e9. doi:10.1016/j.cels.2022.10.001Google Scholar PubMed DOI