Immunology Program

Spatially restricted immune and microbiota-driven adaptation of the gut.

Mayassi T, Li C, Segerstolpe Å, et al. Spatially restricted immune and microbiota-driven adaptation of the gut. Nature. 2024. doi:10.1038/s41586-024-08216-zGoogle Scholar PubMed DOI

Neuropeptide signalling orchestrates T cell differentiation.

Hou Y, Sun L, LaFleur MW, et al. Neuropeptide signalling orchestrates T cell differentiation. Nature. 2024. doi:10.1038/s41586-024-08049-wGoogle Scholar PubMed DOI

Identifying genetic variants that influence the abundance of cell states in single-cell data.

Rumker L, Sakaue S, Reshef Y, et al. Identifying genetic variants that influence the abundance of cell states in single-cell data. Nature genetics. 2024. doi:10.1038/s41588-024-01909-1Google Scholar PubMed DOI

Emerging biochemical, microbial and immunological evidence in the search for why HLA-B∗27 confers risk for spondyloarthritis.

Brown EM, Nguyen PNU, Xavier RJ. Emerging biochemical, microbial and immunological evidence in the search for why HLA-B∗27 confers risk for spondyloarthritis. Cell chemical biology. 2024. doi:10.1016/j.chembiol.2024.07.012Google Scholar PubMed DOI

B cell tolerance and autoimmunity: Lessons from repertoires.

Deguine J, Xavier RJ. B cell tolerance and autoimmunity: Lessons from repertoires. The Journal of experimental medicine. 2024;221(9). doi:10.1084/jem.20231314Google Scholar PubMed DOI

Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation.

Neale I, Reddy C, Tan ZY, et al. Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation. Science advances. 2024;10(29):eadn2339. doi:10.1126/sciadv.adn2339Google Scholar PubMed DOI

Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis.

Thomas MF, Slowikowski K, Manakongtreecheep K, et al. Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis. Nature medicine. 2024. doi:10.1038/s41591-024-02895-xGoogle Scholar PubMed DOI

Airway hillocks are injury-resistant reservoirs of unique plastic stem cells.

Lin B, Shah VS, Chernoff C, et al. Airway hillocks are injury-resistant reservoirs of unique plastic stem cells. Nature. 2024. doi:10.1038/s41586-024-07377-1Google Scholar PubMed DOI

An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission.

Ding J, Garber JJ, Uchida A, et al. An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission. Nature communications. 2024;15(1):3344. doi:10.1038/s41467-024-47647-0Google Scholar PubMed DOI

A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children.

de Smith AJ, Wahlster L, Jeon S, et al. A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children. Cell genomics. 2024:100526. doi:10.1016/j.xgen.2024.100526Google Scholar PubMed DOI