Center for the Development of Therapeutics

MacDonald BT, Elowe NH, Garvie CW, Kaushik VK, Ellinor PT. Identification of a new Corin atrial natriuretic peptide-converting enzyme substrate: Agouti-signaling protein (ASIP). bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.04.26.538495Google ScholarPubMedDOI

Wieder N, Fried J, Kim C, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Cell metabolism. 2023. doi:10.1016/j.cmet.2023.03.018Google ScholarPubMedDOI

Bian Y, Kwon JJ, Liu C, Margiotta E, Shekhar M, Gould AE. Target-driven machine learning-enabled virtual screening (TAME-VS) platform for early-stage hit identification. Frontiers in molecular biosciences. 2023;10:1163536. doi:10.3389/fmolb.2023.1163536Google ScholarPubMedDOI

Wieder N, Fried JC, Kim C, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.02.19.529127Google ScholarPubMedDOI

Cimini BA, Chandrasekaran SN, Kost-Alimova M, et al. Optimizing the Cell Painting assay for image-based profiling. Nature protocols. 2023. doi:10.1038/s41596-023-00840-9Google ScholarPubMedDOI

Lee S, Hoyt S, Wu X, et al. Velcrin-induced selective cleavage of tRNA(TAA) by SLFN12 causes cancer cell death. Nat Chem Biol. 2022. doi:10.1038/s41589-022-01170-9Google ScholarPubMedDOI

Rohban MH, Fuller AM, Tan C, et al. Virtual screening for small-molecule pathway regulators by image-profile matching. Cell Syst. 2022. doi:10.1016/j.cels.2022.08.003Google ScholarPubMedDOI

Chaffin M, Papangeli I, Simonson B, et al. Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy. Nature. 2022. doi:10.1038/s41586-022-04817-8Google ScholarPubMedDOI

Fang L, Ford-Roshon D, Russo M, et al. RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition. Nat Commun. 2022;13(1):3181. doi:10.1038/s41467-022-30794-7Google ScholarPubMedDOI

Shekhar M, Smith Z, Seeliger M, Tiwary P. Protein Flexibility and Dissociation Pathway Differentiation Can Explain Onset Of Resistance Mutations in Kinases. Angew Chem Int Ed Engl. 2022. doi:10.1002/anie.202200983Google ScholarPubMedDOI